Table 3.
Summary of Genes Other Than NOD2 With a Significant Impact on Postoperative Recurrence of CD
| Study | Identified Genetic Factor Associated With Recurrence | Statistical Analysis | Definition of Recurrence | Change in Risk | P |
|---|---|---|---|---|---|
| Gerich 2013 | IRF8 | Univariate survival analysis. | Repeat surgery | HR: 0.6 | 0.015 |
| LSP1/TNNI2 | No correction for multiple testing. | HR: 1.4 | 0.04 | ||
| PTGER4 | HR: 1.3 | 0.04 | |||
| DAP | HR: 1.4 | 0.04 | |||
| FAM49B | HR: 3.2 | <0.001 | |||
| PELI3 | HR: 1.8 | <0.001 | |||
| CHL1 | HR: 2.6 | <0.001 | |||
| PARVB | HR: 0.5 | <0.001 | |||
| STK24 | HR: 1.7 | <0.001 | |||
| Germain 2016 | Homozygosity for the variant at CARD8 snp rs2043211 | Multivariable survival analysis. | Repeat surgery | OR: 7.56 | 0.04 |
| No correction for multiple testing. | |||||
| Laffin 2018 | Homozygosity for the variant at BACH2 snp rs1847472 | Multivariable survival analysis. | Repeat surgery | HR: 1.54 | <0.05 |
| No correction for multiple testing. | |||||
| Sehgal 2012 | Presence of the variant at IRGM rs4958847 | Multivariable survival analysis. | Repeat surgery | NR | 0.007 |
| Corrected for multiple testing. | |||||
| Yang 2014 | Homozygosity for the variant at TNFSF15 snp rs6478108 | Multivariable survival analysis. | Development of stricture | HR: 1.7 | 0.005 |
| No correction for multiple testing. |
NR, not reported.