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. 2022 Nov 4;1(5):pgac248. doi: 10.1093/pnasnexus/pgac248

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© The Author(s) 2022. Published by Oxford University Press on behalf of National Academy of Sciences.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 5. — Anti-NXT-2 antibodies inhibit biofilm formation and increase opsonophagocytic killing. Candida albicans biofilms were incubated with heat-inactivated plasma from (A) CA.KEX1-, NXT-2-, or SHAM-immunized mice and (B) NXT-2- or SHAM-immunized rhesus macaques, with reduced formation in wells with plasma from vaccinated mice and NHPs. (C) and (D) Opsonophagocytic killing of C. albicans and A. fumigatus by macrophages was evaluated in presence of plasma from CA.KEX1-, AF.KEX1-, NXT-2-, and SHAM-immunized mice. Plasma from CA.KEX1-, AF.KEX1-, and NXT-2-immunized mice significantly enhanced fungal killing compared to SHAM. Results are presented relative to macrophage killing of fungi without any added plasma. Statistical significance was determined by Mann–Whitney tests and one-way ANOVA. ^*≤ 0.05, ** < 0.01, and *** < 0.001.