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. 2022 Nov 4;1(5):pgac248. doi: 10.1093/pnasnexus/pgac248

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© The Author(s) 2022. Published by Oxford University Press on behalf of National Academy of Sciences.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 7. — NXT-2 vaccination-associated memory responses. (A) Development of B cell memory was analyzed at baseline, and 1 week following vaccination (PV1) and boost (PV2) with NXT-2 + alum in rhesus macaques. The cell populations analyzed here are the frequency of (i) plasmablasts (CD138 + CD27hiCD19 + CD20 + IgD–IgM-), (ii) switched memory (CD27 + IgD-CD19 + CD20+), and (iii) percentage of switched memory (CD27 + IgD-CD19 + CD20+) B cells that are IgM+ . Memory T-cell populations were also analyzed in the peripheral blood (B) and BALF (C), including the frequency of (i) effector memory and (ii) central memory T cells. Changes in cell populations over time were analyzed by one-way ANOVA. * ≤ 0.05, ^**< 0.01, and *** < 0.001.