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. 2020 Apr 16;2(2):otaa015. doi: 10.1093/crocol/otaa015

TABLE 5.

Side Effects Experienced by Both Current and Previous Cannabis Users

Mild and Tolerable Side Effects Severe or Intolerable Side Effects
Current Users Previous Users Current Users Previous Users P*
Increased appetite 62 (68%) 40 (70%) 7 (8%) 0 (0%) 0.54
Dry mouth 59 (64%) 31 (54%) 4 (4%) 1 (2%) 0.13
Drowsiness or sedation 50 (55%) 33 (58%) 3 (3%) 1 (2%) 0.87
Memory impairment 30 (33%) 17 (30%) 1 (1%) 2 (4%) >0.99
Lack of energy or fatigue 26 (29%) 20 (35%) 5 (5%) 0 (0%) 0.90
Dehydration 19 (21%) 10 (18%) 2 (2%) 0 (0%) 0.54
Confusion 18 (20%) 9 (16%) 1 (1%) 0 (0%) 0.52
Dizziness 16 (17%) 9 (16%) 0 (0%) 0 (0%) >0.99
Bad taste in mouth 15 (16%) 12 (21%) 2 (2%) 3 (5%) 0.30
Diarrhea 14 (15%) 8 (14%) 2 (2%) 0 (0%) 0.83
Anxiety 14 (15%) 17 (30%) 1 (1%) 1 (2%) 0.042
Eye irritation 13 (14%) 6 (11%) 0 (0%) 1 (2%) 0.81
Respiratory complaints 9 (10%) 3 (5%) 0 (0%) 3 (5%) >0.99
Racing heart/palpitations 9 (10%) 5 (9%) 0 (0%) 2 (4%) 0.79
Paranoia 9 (10%) 9 (16%) 0 (0%) 2 (4%) 0.14
Gastrointestinal irritation 9 (10%) 5 (9%) 0 (0%) 0 (0%) >0.99
Depressed mood 9 (10%) 6 (11%) 1 (1%) 0 (0%) >0.99
Nausea/vomiting 8 (9%) 3 (5%) 2 (2%) 0 (0%) 0.37
Sleep disturbance 7 (8%) 4 (7%) 2 (2%) 1 (2%) >0.99
Constipation 6 (7%) 3 (5%) 1 (1%) 0 (0%) 0.74
Sweating 5 (5%) 3 (5%) 1 (1%) 1 (2%) >0.99
Headaches 5 (5%) 5 (9%) 2 (2%) 0 (0%) 0.77
Allergies 4 (4%) 1 (2%) 0 (0%) 0 (0%) 0.65
Shaking/tremor/poor movement control 3 (3%) 3 (5%) 0 (0%) 1 (2%) 0.43
Decreased appetite 3 (3%) 2 (4%) 1 (1%) 0 (0%) >0.99
Panic attack 2 (2%) 1 (2%) 0 (0%) 1 (2%) 0.64
Nasopharyngeal complaints 2 (2%) 3 (5%) 1 (1%) 0 (0%) 0.68
Cannabis hyperemesis 2 (2%) 2 (4%) 1 (1%) 0 (0%) >0.99
Hallucinations 1 (1%) 4 (7%) 0 (0%) 0 (0%) 0.072
Delusions 0 (0%) 6 (11%) 1 (1%) 0 (0%) 0.014

Number of respondents; current users = 89–92; previous users = 56–57.

*P value represents contingency test between current and previous users of all side effects experienced (severe and mild combined) using a χ 2 analysis or Fisher’s exact test where n < 20.