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. 2022 Aug 24;1(4):pgac166. doi: 10.1093/pnasnexus/pgac166

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© The Author(s) 2022. Published by Oxford University Press on behalf of National Academy of Sciences.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 4. — Vegf ^RPE KO mice reveal myopic features while Vhl^RPE KO mice reveal hyperopic features. (A and B) Transmission electron microscope observation of choroids in 10-week-old Vegf^RPE Cont and Vegf^RPE KO (A), and Vhl^RPE Cont and Vhl^RPE KO (B) mouse showing choriocapillaris thinning in Vegf^RPE KO and choriocapillaris vasodilatation in Vhl^RPE KO. Choriocapillaris highlighted by dashed line. Scale bar: 20 µm. (C to J) Choroidal thickness (C and G), axial length (D and H), vitreous chamber depth (E and I) and refraction error (F and J) measurement of Vegf^RPE Cont and Vegf^RPE KO (C to F), and Vhl^RPE Cont and Vhl^RPE KO mouse (G to J) with growth n = 5. *P < 0.05, **P < 0.01, ***P < 0.001, two-tailed Student's t-tests.