Table 1.
Prediction of stool biomarkers.
| Author | Year | Study design | Patient # | Median age (range) | Pre-Op diagnosis | Pouchitis definition | Biomarker | Cutoff (µg/g) |
Method; assay | Association between biomarker and PDAI | Sensitivity (%) | Specificity (%) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Yamamoto | 2015 | Case control | 60 | 34 (21–64) | UC | PDAI ≥ 7 | Fecal calprotectin | 56 | ELISA; Human Calprotectin Kit 9, (Cell Sciences, Canton, MA, USA) |
Endoscopy subscore: r = 0.696 p < 0.0001 Total PDAI: r = 0.626 p < 0.0001 |
100 | 84 |
| Yamamoto | 2015 | Case control | 60 | 34 (21–64) | UC | PDAI ≥ 7 | Fecal lactoferrin | 50 | ELISA; Human Calprotectin Kit 9, (Cell Sciences, Canton, MA, USA) |
Endoscopy subscore: r = 0.676 p < 0.0001 Total PDAI: r = 0.582 p < 0.0001 |
90 | 86 |
| Machiels | 2017 | Prospective cohort | 19 | 45 (35–51) | UC | Symptoms + endoscopic inflammation | Fecal calprotectin | 315.5 | QI; Quantum Blue Calprotectin High range Assay, (Buhlmann Laboratories AG Schonenbuch, Switzerland) | AUC = 0.833 | 83.3 | 72.7 |
| Nishida | 2020 | Retrospective cohort | 49 | 44 (33–54) | UC | mPDAI ≥ 5 | Neutrophil lymphocyte ratio | 2.15 | XE-500 hematology analyzer; (Sysmex, Kobe, Japan) | AUC = 0.68 | 72.2 | 67.7 |
Abbreviations: AUC: area under the curve, ELISA: enzyme linked immunosorbent assay; PDAI: pouchitis disease activity index; pre-op: pre-operative; QI: quantitative immunochromatography; UC: ulcerative colitis;