Table 2.
Association of selected serum markers with pouch inflammation.
| Author | Year | Study design | Patient # | Median age (range) | Pre-Op diagnosis | Pouchitis definition | Biomarker | Association between biomarker and PDAI | Sensitivity (%) | Specificity (%) |
|---|---|---|---|---|---|---|---|---|---|---|
| Lu | 2010 | Prospective cohort | 83 | 43 (29–57) | UC | Endoscopic PDAI ≥ 2 | CRP > 0.7 g/dL |
Endoscopy subscore:
r = 0.28 p = 0.06 AUC pouch body inflammation = 0.63 Total PDAI: NP |
69.7 | 63.6 |
| Matalon | 2015 | Prospective cohort | 71 | 44 (35–52) | UC | PDAI ≥ 7 | CRP |
Endoscopy subscore: NP Total PDAI: r= 0.584 p= 0.001 |
NP | NP |
| Matalon | 2015 | Prospective cohort | 71 | 44 (35–52) | UC | PDAI ≥ 7 | Serum A1AT >189 mg/dL |
Endoscopy subscore: NP Total PDAI: r= 0.583 p< 0.001 |
55.6 |
100 |
| Wang | 2013 | Prospective cohort | 185 | 46 (29–61) | UC (163) CD (3) Indeterminate (18) |
mPDAI ≥ 5 | Serum serotonin |
Endoscopy subscore: OR 1.8, 95% CI 1.2–2.8 p< 0.05 Total PDAI: No correlation |
NP | NP |
| Sandborn | 1995 | Prospective cohort | 52 | 36–64 (26–77) | UC (47) FAP (5) |
PDAI ≥ 7 | p-ANCA |
Endoscopy subscore: Correlation to all findings except ulceration Total PDAI: r= 0.39 p< 0.01 |
NP | NP |
| Yasuda | 1998 | Case control | 49 | 32–37 (22–56) | UC | Pouchitis by St. Mark’s criteria | p-ANCA | No correlation | NP | NP |
| Werner | 2013 | Case control | 41 | 19–26 (11–49) | UC (36) FAP (5) |
PDAI ≥ 7 | Serum anti-GP-2 | Significantly higher level compared to controls (p< 0.05) | NP | NP |
Abbreviations: A1AT: alpha 1 anti-trypsin; AUC: area under the curve; CD: Crohn’s disease; CI: confidence interval; CRP: C-reactive protein; FAP: familial adenomatous polyposis; GP-2: glycoprotein 2; IgG: immunoglobulin G; OR: odds ratio; p-ANCA: perinuclear anti-neutrophil cytoplasmic antibody; PDAI: pouchitis disease activity index; pre-op: pre-operative; UC: ulcerative colitis