Table 4.
Association of fecal lactoferrin with pouch inflammation.
| Author | Year | Study design | Patient # | Median age (range) | Pre-op diagnosis | Pouchitis definition | Biomarker | CutOff (µg/g) | Method; Assay |
Association between biomarker and PDAI | Sensitivity (%) | Specificity (%) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Scarpa | 2011 | Prospective cohort | 32 | 50 (43–58) | UC | PDAI ≥ 7 | Fecal lactoferrin | <7 | ELISA; IBD-SCAN (TechLab, Blacksburg, VA) | Correlated with mucosal ulcers and histologic pouchitis | NP | NP |
| Parsi | 2004 | Prospective cohort | 60 | 42–53 (36–57) | UC | PDAI ≥ 7 | Fecal lactoferrin |
7 13 |
NP |
Endoscopy subscore: r = 0.73 p < 0.001 Total PDAI: r = 0.73 p = 0.001 AUC = 0.992 |
100 97 |
85 92 |
| Lim | 2008 | Prospective cohort | 32 | 47 (40–53) | UC | PDAI ≥ 7 | Fecal lactoferrin | ≥7.25 | ELISA; IBD-EZ VUE (TechLab, Blacksburg, VA) | NP | 100 | 82 |
| Gonsalves | 2013 | Prospective cohort | 85 | 42 (36–49) | UC | PDAI ≥ 7 | Fecal lactoferrin | ≥7.25 | ELISA; IBD EZ VUE. (TechLab, Blacksburg, VA) |
NP | 100 | 92 |
Abbreviations:: AUC: area under the curve; ELISA: enzyme linked immunosorbent assay; IBD: inflammatory bowel disease; NP: not provided; PDAI: pouchitis disease activity index; pre-op: pre-operative; UC: ulcerative colitis