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. 2022 Apr 15;1(1):pgac017. doi: 10.1093/pnasnexus/pgac017

Table 1.

Fractions of functions that are RoFs, non-NCF RoFs, or NCFs, in the space of all Inline graphicBFs (f0) or in the reference biological dataset (f1). E( = f1/f0) is the enrichment ratio; it indicates the extent of the over-representation of such functions in the reference dataset. Over-representation is highest for NCFs but clearly non-NCF RoFs are also highly over-represented. Computations are reported for functions with k ≤ 8 inputs.

k RoF non-NCF RoF NCF
f 0 f 1 E f 0 f 1 E f 0 f 1 E
1 0.5 1.000 2.000 0 0 0.5 1.000 2.00
2 0.5 0.977 1.953 0 0 0.5 0.977 1.95
3 0.250 0.917 3.670 0 0 0.25 0.917 3.67
4 1.27 × 10−2 0.946 74.495 1.46 × 10−3 5.43 × 10−2 37.04 1.12 × 10−2 8.91 × 10−1 79.38
5 3.52 × 10−6 0.853 2.42 × 105 1.04 × 10−6 0.083 7.99 × 104 2.47 × 10−6 0.769 3.11 × 105
6 1.91 × 10−14 0.776 4.06 × 1013 9.12 × 10−15 0.150 1.64 × 1013 9.97 × 10−15 0.626 6.28 × 1013
7 2.95 × 10−32 0.804 2.73 × 1031 1.86 × 10−32 0.137 7.39 × 1030 1.09 × 10−32 0.667 6.11 × 1031
8 2.92 × 10−69 0.756 2.59 × 1068 2.18 × 10−69 0.156 7.14 × 1067 7.41 × 10−70 0.600 8.10 × 1068