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. 2022 Oct 26;1(5):pgac243. doi: 10.1093/pnasnexus/pgac243

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© The Author(s) 2022. Published by Oxford University Press on behalf of the National Academy of Sciences.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 2. — Biological properties of SDV genes. (A) Following meta-analysis SDV genes with higher variation in males and females are enriched for terms related to various signaling pathways, immune response, and sex-hormone response. (B) Genes with higher variability in males are enriched for terms related to estrogen and immune response in breast tissue. (C) Following meta-analysis, genes with higher variability in females are enriched for targets of two transcription factors. (D) SDV genes identified in breast tissue show highly cell-type specific expression in breast epithelial tissue (P-value calculated using the Mann–Whitney U test). Higher τ indicates greater cell-type specificity. (E) Genes with higher variability in females in the thyroid are significantly enriched for genes associated with Graves’ disease (P-value calculated using a hypergeometric test).