Skip to main content
. 2022 Aug 5;2(1):108–120. doi: 10.1016/j.gastha.2022.07.015

Table 1.

Comparative Liver Anatomy Across Commonly Used Models of Intrahepatic Biliary Biology

Zebrafish
 Rat
 Mouse
 Human
graphic file with name fx1.gif graphic file with name fx2.gif graphic file with name fx3.gif graphic file with name fx4.gif Citations
Lobation Bilobated; Dorsal lobe (DL) and ventral lobe (VL) Lobated; Left lobe (LL), median lobe (ML), right lobe (RL), caudate lobe (CL) Lobated; Left lobe (LL), median lobe (ML), right lobe (RL), caudate lobe (CL) Not lobated; However, the human liver is described in segments of left, right, and caudate (not shown) lobes 39,40
Gallbladder (G) Present Absent Present Present 41,42
Hepatocyte zonation Absent Present Present Present 46
Lobule organization graphic file with name fx5.gif graphic file with name fx6.gif 40,43, 44, 45
Portal triad Absent; bile ducts intermittently dispersed Present Present Present (Same as above)
Hepatic artery Poorly identified/unidentified Present Present Present 45
Intrahepatic bile duct heterogeneity studies • Small and large ducts • Small and large ducts • Small and large ducts • Small and large ducts 21,23,47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57
• scRNA-seq • scRNA-seq • Proliferation preference(clonal assays) • scRNA-seq
• Small and large BECs • ST14 and Sox9EGFP high and low subpopulations • snRNA-seq
• scRNA-seq