Fig. 1. Study schema.
Twenty rhesus macaques were immunized with 1 × 1011 vp (n = 10) or 5 × 1010 vp (n = 10) Ad26.COV2.S. The study start was staggered, and half of the animals in each dose group were followed for 230 or 315 days. Blood was collected longitudinally from days 0 to day 230 or 315 after immunization to evaluate the durability of single-dose Ad26.COV2.S. On day 230 or 315, all the macaques received a boost immunization with 5 × 1010 vp Ad26.COV2.S (n = 10) or Ad26.COV2.S.351 (n = 10). vp, viral particles; D, day.