Table 3B.
Results for the Corrosives Study.
| OptiSafe and Updated OptiSafe Consensus Results for Corrosives | ||||||||
|---|---|---|---|---|---|---|---|---|
| # | Chemical Name (CASRN) | In vivo GHS1 | OptiSafe |
Updated OptiSafe |
||||
| R1 | Cons1 | R1 | R2 | R3 | Cons | |||
| 19 | Pyridine (110–86-1) | 1 | 673.8 (1) | 1 | 600.6 (1) | 751.1 (1) | 1063.9 (1) | 1 |
| 20 | Trichloroacetic acid (30%) (76–03-9) | 1 | 2,754,228.7 (1) | 1 | 74.8 (1) | 71.4 (1) | 72.1 (1) | 1 |
| 21 | 2,2-Dimethylbutanoic acid | (595–37-9) | 1 | 761.1 (1) | 1 658.5 (1) | 1070.0 (1) | 1510.6 (1) | 1 |
| 22 | Diethylethanolamine (100–37-8) | 1 | 3020.0 (2/1) | 2/1 | 20.6 (2/1) | 20.7 (2/1) | 20.1 (2/1) | 2/1 |
| 23 | m-Phenylene diamine (108–45-2) | 1 | CNM | CNM | CNM | CNM | CNM | CNM |
| 24 | Sodium salicylate (54–21-7) | 1 | 87.9 (1) | 1 | 98.3 (1) | 104.1 (1) | 96.9 (1) | 1 |
| 25 | Benzoic acid (65–85-0) | 1 | 640.5 (1) | 1 | 196.4 (1) | 239.7 (1) | 171.3 (1) | 1 |
| 26 | Tetrahydrofuran (109–99-9) | 1 | 44.1 (2) | 2 | 27.3 (2) | 26.6 (2) | 37.3 (2) | 2 |
| 27 | Methylpentynol (77–75-8) | 1 | 105.9 (1) | 1 | 70.1 (1) | 86.1 (1) | 72.3 (1) | 1 |
| 28 | 1-Naphthalene acetic acid Na salt (61–31-4) | 1 | 350.3 (1) | 1 | 108.6 (1) | 112.6 (1) | 91.8 (1) | 1 |
| 29 | Dibenzoyl-L-tartaric acid (2743-38-6) | 1 | 83,176.4 (2/1) | 2/1 | 42.7 (2/1) | 43.3 (2/1) | 43.5 (2/1) | 2/1 |
| 30 | bis-(3-Aminopropyl)-tetramethyldisiloxane (2469–55-8) | 1 | 3311.3 (2/1) | 2/1 | 17.2 (2/1) | 19.7 (2/1) | 19.2 (2/1) | 2/1 |
| 31 | 4,4′ -(4,5,6,7-Tetrabromo-3H-2,1-benzoxathiol-3-ylidene)bis[2,6-dibromophenol] S,S-dioxide (4430–25-5) | 1 | CNM | CNM | CNM | CNM | CNM | CNM |
| 32 | 2-Methylbutyric acid (116–53-0) | 1 | 3981.1 (2/1) | 2/1 | 21.8 (2/1) | 22.7 (2/ 1) | 23.4 (2/ 1) | 2/1 |
| 33 | Paraformaldehyde (30525–89-4) | 1 | 38.0 (2) | 2 | 65.0 (1) | 38.3 (2) | 47.8 (1) | 1 |
| 34 | Methoxyethyl acrylate (3121–61-7) | 1 | 66.3 | (1) | 1 93.0 | (1) 54.0 | (1) 56.8 (1) | 1 |
| 35 | 2-Hydroxy isobutyric acid (594–61-6) | 1 | 234,422.9 (1) | 1 | 54.4 (1) | 54.8 (1) | 53.3 (1) | 1 |
| 36 | alpha-Ketoglutaric acid (328–50-7) | 1 | 1,905,460.7 (1) | 1 | 71.6 (1) | 72.8 (1) | 70.7 (1) | 1 |
| 37 | beta-Resorcylic acid (89–86-1) | 1 | 51,286.1 (2/1) | 2/1 | 41.1 (2/ 1) | 39.7 (2/1) | 39.1 (2/1) | 2/1 |
| 38 | Sodium hydrogen sulfate (7681-38-1) | 1 | 5,370,318.0 (1) | 1 | 84.6 (1) | 85.7 (1) | 84.1 (1) | 1 |
| 39 | 1-Naphthaleneacetic acid (solid) (86–87-3) | 1 | 141.4 (1) | 1 | 121.7 (1) | 203.1 (1) | 141.3 (1) | 1 |
| 40 | Quinacrine (69–05-6) | 1 | 264.3 (1) | 1 | 159.8 (1) | 349.6 (1) | 122.7 (1) | 1 |
| 41 | Benzenesulphonylchloride (98–09-9) | 1 | 1096.5 (2/1) | 2/1 | CNM | 18.8 (2/1) | 20.5 (2/1) | 2/1 |
| 42 | 1,2,4-Triazole, sodium salt (41253–21-8) | 1 | 206.6 (1) | 1 | 46.0 (1) | 40.2 (2) | 46.1 (1) | 1 |
| 43 | 4-(1,1,3,3-Tetramethylbutyl)phenol (140–66-9) | 1 | 110.8 (1) | 1 | 158.0 (1) | 139.3 (1) | 127.6 (1) | 1 |
| 44 | 1-Chloroctan-8-ol (23144–52-7) | 1 | 47.4 (2) | 2 | 30.8 (2) | 32.7 (2) | 32.0 (2) | 2 |
| 45 | 2-Benzyl-4-chlorophenol (120–32–1) | 1 | 79.8 (1) | 1 | 155.5 (1) | 147.6 (1) | 142.0 (1) | 1 |
| 46 | 1,2-Benzisothiazol-3(2H)-one (2634-33-5) | 1 | 200.5 (1) | 1 | 171.0 (1) | 311.7 (1) | 271.3 (1) | 1 |
| 47 | Chlorhexidine (55–56-1) | 1 | 121.0 (1) | 1 | 271.8 (1) | 331.8 (1) | 350.0 (1) | 1 |
| 48 | 2-Hydroxy isobutyric acid ethyl ester (80–55-7) | 1 | 54.9 (2) | 2 | 120.6 (1) | 157.6 (1) | 120.7 (1) | 1 |
| 49 | Hydroxyethyl acrylate (818–61-1) | 1 | 76.3 (1) | 1 | 105.3 (1) | 79.3 (1) | 57.8 (1) | 1 |
| 50 | (3-Aminopropyl)triethoxy silane (919–30-2) | 1 | 143.8 (1) | 1 | 44.4 (2) | 33.6 (2) | 31.5 (2) | 2 |
| 51 | 2-Nitro-4-thiocyanatoaniline (54029–45-7) | 1 | 503.6 (1) | 1 | CNM | 243.3 (1) | 182.8 (1) | 1 |