TABLE 5.
IgG antibodies to proteins elicited by conjugates of S. sonnei and S. flexneri 2a O-SPs bound to CRM9 or rEPA
| Protein (lot, n) | Gm ELISA titer (25th–75th centiles)
|
Fold rise at 26 wk over prevaccination level | ||||
|---|---|---|---|---|---|---|
| Prevaccination | Postvaccination
|
|||||
| 3 days | 1 wk | 4 wk | 26 wk | |||
| CRM9 | ||||||
| S. sonnei-CRM9 (68210, 22) | 1.10 (0.5–1.8) | 1.28 (0.7–2.6) | 6.37 (2.4–16) | 8.89 (3.0–22) | 2.34 (1.1–5.4) | 2.1 |
| S. sonnei-CRM9succ (68211, 30) | 1.05 (0.5–2.6) | 1.23 (0.5–2.7) | 5.03 (2.9–11) | 6.08 (2.8–11) | 2.03 (1.3–4.4) | 1.9 |
| S. flexneri-CRM9succ (68208, 33) | 0.90 (0.4–1.4) | 0.94 (0.5–1.3) | 2.54 (1.1–7.5) | 4.28 (2.3–12) | 1.83 (0.7–4.1) | 2.0 |
| rEPA | ||||||
| S. sonnei-rEPAsucc (68212, 30) | 0.44 (0.2–0.9) | 0.42 (0.2–0.9) | 0.87 (0.3–2.4) | 1.65 (0.5–4.9) | 0.92 (0.5–2.0) | 2.1 |
| S. flexneri-rEPAsucc (68209, 31) | 0.43 (0.3–0.9) | 0.54 (0.3–1.1) | 1.30 (0.5–4.8) | 1.80 (0.6–6.5) | 1.05 (0.5–2.3) | 2.4 |