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. 2022 Dec 30;17(12):e0279464. doi: 10.1371/journal.pone.0279464

Table 4. Associations between parish and clinical outcomes stratified by age.

Age strata District Parish Intervals* Interval risk of any symptomatic malaria Interval risk of any microscopic parasitemia Risk of symptomatic malaria if microscopic parasitemia present**
n (%) RR (95% CI) p-value n (%) RR (95% CI) p-value % RR (95% CI) p-value
< 5 years Busia Buteba 260 39 (15.0) Reference 63 (24.2) Reference 61.9 Reference
Tororo Kayoro 439 45 (10.3) 0.68 (0.44–1.06) 0.09 85 (19.4) 0.81 (0.55–1.19) 0.28 52.9 0.86 (0.56–1.31) 0.48
Osukuru 247 59 (23.9) 1.60 (1.05–2.42) 0.03 81 (32.8) 1.41 (0.94–2.12) 0.10 72.8 1.18 (0.79–1.76) 0.43
5–15 years Busia Buteba 162 18 (11.1) Reference 70 (43.2) Reference 25.7 Reference
Tororo Kayoro 354 40 (11.3) 1.01 (0.57–1.82) 0.96 138 (39.0) 0.90 (0.67–1.21) 0.49 29.0 1.13 (0.64–2.00) 0.68
Osukuru 204 41 (20.1) 1.81 (1.01–3.27) 0.047 92 (45.1) 1.04 (0.76–1.43) 0.79 44.6 1.74 (0.98–3.09) 0.06
> 15 years Busia Buteba 225 6 (2.7) Reference 41 (18.2) Reference 14.3 Reference
Tororo Kayoro 407 11 (2.7) 1.07 (0.36–3.18) 0.91 49 (12.0) 0.64 (0.38–1.08) 0.10 22.5 1.53 (0.57–4.15) 0.40
Osukuru 228 14 (6.1) 2.38 (0.80–7.08) 0.12 32 (14.0) 0.78 (0.43–1.39) 0.39 43.8 2.99 (1.15–7.78) 0.03

* approximately 28-day periods of observation between routine visits

** Number of intervals with any symptomatic malaria diagnosed / number of intervals with any microscopic parasitemia detected