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Histological confirmation of STEC-induced renal injury. Kidneys were removed from an uninfected control mouse (A), a CWG308-treated mouse which died 4 days after challenge with 97MW1 (B), and two different CWG308:pJCP-Gb3-treated mice which were alive and well 12 days after challenge with 97MW1 (C and D). Kidneys were fixed, sectioned, and stained with hematoxylin and eosin as described in Materials and Methods and examined by light microscopy at a magnification of ×400.
