Table 1. Demographic and clinical characteristics of included studies.

Author	Country	Year published	Trial registration	Agent	Comparator	SGLT-2 inhibitors(n)	Control(n)	Follow-up time
Bode B et al [10]	17 countries	2013	NCT01106651	Traditional hypoglycemic treatment+Canagliflozin	Traditional hypoglycemic treatment+Placebo	71	74	26 weeks
Cefalu WT et al [11]	19 countries	2013	NCT00968812	Canagliflozin+Metformin	Glimepiride+Metformin	102	96	52 weeks
Bolinder J et al [12]	5 countries	2014	NCT00855166	Dapagliflozin+Metformin	Placebo+Metformin	69	71	102 weeks
Fadini GP et al [13]	Italy	2017	NCT02327039	Traditional hypoglycemic treatment+Dapagliflozin	Traditional hypoglycemic treatment+Placebo	15	16	12 weeks
Ito D et al [14]	Japan	2017	UMIN000022651	Traditional hypoglycemic treatment+Iapagliflozin	Traditional hypoglycemic treatment+Pioglitazone	32	34	24 weeks
Han E et al [15]	Korea	2020	NCT02875821	Ipragliflozin+Metformin +Pioglitazone	Metformin+Pioglitazone	29	15	24 weeks
McCrimmon RJ et al [16]	11 countries	2020	NCT03136484	Canagliflozin+Metformin	Semaglutide+Metformin	23	22	52 weeks
Nakaguchi H et al [17]	Japan	2020	UMIN000027614	Traditional hypoglycemic treatment+Empagliflozin	Traditional hypoglycemic treatment+Liraglutide	31	30	24 weeks
Yamakage H et al [18]	Japan	2020	UMIN000021479	Traditional hypoglycemic treatment+Dapagliflozin	Traditional hypoglycemic treatment	26	24	24 weeks
Wolf VLW et al [19]	Brazil	2021	NCT02919345	Dapagliflozin+Metformin	Glibenclamide+ metformin	44	45	12 weeks
Chehrehgosha H et al [20]	Iran	2021	IRCT20190122042450N3	Empagliflozin	Pioglitazone	35	34	24 weeks
Horibe K et al [21]	Japan	2022	UMIN000020239	Traditional hypoglycemic treatment+Dapagliflozin	Traditional hypoglycemic treatment	26	24	24 weeks
Inoue H et al [22]	Japan	2019	UMIN000018839	Traditional hypoglycemic treatment+Ipragliflozin	Traditional hypoglycemic treatment	24	24	24 weeks
Kayano H et al [23]	Japan	2020	UMIN000023834	Traditional hypoglycemic treatment+Dapagliflozin	Traditional hypoglycemic treatment	36	38	24 weeks
Kinoshita T et al [24]	Japan	2020	UMIN000021291	Dapagliflozin	Pioglitazone	32	33	28weeks
Tsurutani Y et al [25]	Japan	2018	UMIN000014738	Traditional hypoglycemic treatment+Ipragliflozin	Traditional hypoglycemic treatment	52	49	12 weeks
Shimizu M et al [26]	Japan	2019	UMIN000022155	Traditional hypoglycemic treatment+Dapagliflozin	Traditional hypoglycemic treatment	33	24	24 weeks
Zeng Y et al [27]	Taiwan	2022	NCT03458715	Empagliflflozin+Premixed insulin	Linagliptin+Premixed insulin	46	51	24 weeks