Table 1.
Cox proportional hazard analysis of factors associated with mortality in patients with bronchiectasis
| aHR * | 95% confidence interval | P value | |
|---|---|---|---|
| Demographic data | |||
| Female | 8.14 | 2.39–27.78 | .001 |
| BMI, kg/m² (< 24.9) | 0.12 | 0.04–0.36 | .0002 |
| Etiology (postinfection nontuberculosis) | 0.13 | 0.04–0.52 | .004 |
| Comorbidities | |||
| Diabetes | 3.92 | 1.09–14.10 | .037 |
| COPD | 4.03 | 1.28–12.74 | .018 |
| Current smoker | 22.46 | 2.03–248.74 | .011 |
| Worsening of symptoms, previous year | |||
| Emergency visit, (twice) | 36.77 | 4.10–330.14 | .001 |
| Exacerbation | 3.78 | 1.05–13.65 | .042 |
| Sputum color change | 8.19 | 2.45–27.38 | .001 |
| Use of antibiotic due to exacerbation | 11.17 | 2.25–55.48 | .003 |
| Spirometric data | |||
| FEV1 % predicted (< 53.5) | 6.51 | 1.60–26.46 | .009 |
| FVC % predicted (< 66.5) | 36.17 | 5.72–228.59 | .0001 |
| Quality of life, EQ-5D-3L | |||
| Mobility | 5.57 | 1.46–21.21 | .012 |
| Anxiety/depression | 2.91 | 0.82–10.39 | .100 |
| Valuation (< 0.65) | 0.57 | 0.16–2.03 | .382 |
| VAS (<70) | 4.41 | 1.33–14.59 | .015 |
| Prophylactic measures | |||
| Absence of respiratory physiotherapy | 41.32 | 4.97–343.68 | .001 |
| Influenza vaccination | 0.09 | 0.02–0.36 | .001 |
| Absence of pneumococcal vaccination | 7.00 | 2.90–24.48 | .002 |
aHR* = adjusted hazard ratio, BMI= body mass index; COPD = chronic obstructive pulmonary disease; FEV1 = forced expiratory volume in 1 second; FVC = forced vital capacity; VAS = Visual Analogue Scale.