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. 2022 Dec 23;2022:8704016. doi: 10.1155/2022/8704016

Figure 2.

Figure 2

Inhibition of PFKFB3 and Gsdmd gene knockout can improve the prognosis of septic mice. (a) The coexpression of PFKFB3 and GSDMD was analyzed by MEM. (b, c) The LPS-induced PFKFB3 expression was inhibited by 3PO in Caco-2 cells. (d) GSDMD and GSDMD-NT expression in intestinal tissues of wild-type and Gsdmd−/− mice after sham or CLP operation. (e) Survival rates were calculated in different groups. The values were shown as mean ± SD (n = 5 per group in (d) and (e)). Statistical analysis was performed using a t-test (e) and log-rank test (c). ∗∗∗P < 0.001 versus sham group; #P < 0.05, ##P < 0.01, and ###P < 0.001 versus CLP group.