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. 2022 Dec 30;12:22576. doi: 10.1038/s41598-022-26071-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Comparisons for analysis of differential DNAme associated with SSRI exposure and maternal depression in the discovery cohort. (A) The SSRI model investigates SSRI exposure in the full cohort (n = 64), comparing SSRI-exposed (n = 20) to SSRI non-exposed (n = 44) cases, adjusting for mean maternal Hamilton Depression score across gestation. (B) The SSRIs in maternal depression model investigates SSRI exposure in all maternally-depressed cases (mean maternal Hamilton Depression score > 8, n = 34), this model compares SSRI-exposed, maternally depressed cases (n = 14) to SSRI non-exposed, maternally depressed cases (n = 20). (C) The maternal depression without SSRIs model investigates the effect of maternal depression in cases not exposed to SSRIs (n = 44), this model compares SSRI non-exposed, maternally depressed cases (n = 20) to SSRI non-exposed and not maternally depressed cases (n = 24).