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. 2022 Dec 30;12:22613. doi: 10.1038/s41598-022-26495-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Function analysis. (a) The GSEA enrichment method was used to annotate the GO gene function of the DEGs, and the two items with the highest and lowest enrichment scores are visualized according to the enrichment scores. (b) The GSEA enrichment method was used to annotate the GO gene function of the DEGs, and the top 15 are visualized according to the enrichment scores. (c) The KEGG pathway enrichment analysis of DEGs was carried out by GSEA enrichment method, and the two items with the highest and lowest enrichment scores are visualized according to the arrangement of enrichment scores. (d) The KEGG pathway enrichment analysis of DEGs was carried out by GSEA enrichment method, and the top 15 are visualized according to the enrichment score. (e) The pathway enrichment analysis of DEGs was carried out according to the MSigDb dataset by the GSEA enrichment method, and the two items with the highest and lowest enrichment scores and ferroptosis related pathway are visualized according to the arrangement of enrichment scores. (f) The pathway enrichment analysis of DEGs was carried out according to the MSigDb dataset by GSEA enrichment method, and the top 15 are visualized according to the enrichment score. (adj. p < 0.05 was considered statistically significant).