Table 2.

Results of the voxel-based group comparison (SPM12) showing the significant glucose metabolism differences in visual snow syndrome (VSS) patients compared to healthy controls (CON)

Cluster level		Voxel level		Peak voxel Talairach coordinate			Cluster peak intensity	Cluster location
PFWE-corr	Kext	Pheight (FWE)	T score	X	Y	Z	Δ% (%)	Anatomical region
(A.1) VSS > CON (pheight-FWE < 0.05 at voxel-level)
< 0.0001	656	< 0.0001	11.7	− 15	− 75	17	+ 24	L calcarine (BA18)
		0.001	8.7	− 12	− 68	8		L lingual gyr (BA17)
< 0.0001	970	0.001	8.6	9	− 69	12	+ 24	R calcarine (BA17)
		0.002	8.4	8	− 83	3		R calcarine (BA17)
(A.2) VSS > CON (pheight-uncorr < 0.001 at voxel-level)
< 0.0001	11,494	< 0.0001	11.7	− 15	− 75	17	+ 24	L Cuneus (BA18)
		< 0.0001	8.7	− 12	− 68	8		L calcarine (BA17)
		< 0.0001	8.6	9	− 69	12		R calcarine (BA17)
		< 0.0001	8.0	− 12	− 101	− 3		L occip pole (BA17)
		< 0.0001	7.0	− 2	− 87	0		L lingual gyr (BA17)
		< 0.0001	6.8	50	− 75	− 6		R inf occip gyr (BA19)
0.004	1277	< 0.0001	6.6	45	− 63	− 53	+ 37	R CBL_VIIb
		< 0.0001	6.4	38	− 60	− 60		R CBL_VIII
(B) VSS < CON (pheight-uncorr < 0.001 at voxel-level)
< 0.0001	12,006	< 0.0001	6.3	− 12	− 38	− 5	− 14	L parahpc gyr
		< 0.0001	6.2	20	− 18	− 23		R parahpc gyr
		< 0.0001	6.0	− 15	− 11	− 17		L HpC
		< 0.0001	5.9	33	− 38	2		R HpC

At voxel level p_{height-cluster FWE-corr} < 0.05 (A.1) and p_{height-cluster uncorr} < 0.001 (A.2 and B) with cluster extent 200 voxels

BA Brodmann area, CBL cerebellum, HpC hippocampus, parahpc parahippocampus, L left, R right