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. 2022 Dec 31;4(4):lqac097. doi: 10.1093/nargab/lqac097

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© The Author(s) 2022. Published by Oxford University Press on behalf of NAR Genomics and Bioinformatics.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Identification of internal time-telling genes in human dermis and epidermis. (A) Predictive biomarkers from human dermis (left panels) and epidermis (right panels) for optimal parameter choice (Supplementary Figure S5A). Genes assigned to SPC1 or SPC2 as well as their coefficients are shown. (B) Expression profiles of the predictor genes in each sample in our cohort in the dermis (left) and the epidermis (right) represented in SPC space. Colors indicate the internal time of the subject samples. ZeitZeiger was used to identify biomarkers of internal phase and was run with all ∼11000 expressed genes, separately for the dermis and the epidermis.