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. 2022 Dec 23;24:197–235. doi: 10.1016/j.bioactmat.2022.11.019

Fig. 5.

Fig. 5

Wound dressings with antibacterial properties. (A) Chitosan (CS)/konjac glucomannan (KGM) based hydrogels. (i) Self-healing properties of the CS-KGM hydrogels. (ii) Antibacterial efficiency of CS-KGM hydrogels against S. aureus and E. coli. (iii) Wound healing capacity of CS-KGM hydrogels in a rabbit model compared to CS hydrogels and untreated wounds. (iv) Hematoxylin and eosin (H&E) staining of wounds treated with CS or CS-KGM hydrogels or left untreated. Reprinted and adapted with permission from Chen et al., 2018 [105]. (B) Quaternized chitosan (QCS), Pluronic®F127 (PF) and curcumin (Cur) hydrogels (Cur-QCS/PF). (i) QCS/PF1.0 hydrogel and Cur-QCS/PF1.0 hydrogel disks were cut into pieces, mixed, and self-healed. Scheme and picture of the self-healing capacity with disks and randomly shaped hydrogels. (ii) E. coli and S. aureus cell viability when contacting QCS/PF hydrogels with different degrees of crosslinking. (iii) Wound closure from day 0 to day 15 of wounds treated with commercial TegadermTM Film, QCS/PF1.0 hydrogels, or Cur-QCS/PF1.0 hydrogels. (iv) Histomorphological evaluation of wounds treated with commercial TegadermTM Film, QCS/PF1.0 hydrogels, or Cur-QCS/PF1.0 hydrogels; blood vessels: yellow arrows, hair follicles: green arrows, boundary of epithelium and dermis: blue lines, completed epithelium: yellow hexagram. Reprinted and adapted with permission from Qu et al., 2018 [116].