Table 4.

Highlights of reviewed studies about growth factor application in hydrogels for wound healing.

Biomaterials	Growth factor	Concentration	In vivo	Main result	Ref
Heparin	hEGF	1 cm2 Hydrogels soaked in PBS containing 100 ng hEGF	+	Accelerated wound closure compared to control group. Improved granulation tissue formation, capillary formation, and epithelialization in Heparin/EGF compared to control	[36]
Heparin-Poloxamer	bFGF/aFGF	N/A	+	About 43% release of aFGF and 24% of bFGF was measured from heparin hydrogel within 10 days associated with stronger binding of bFGF to heparin. Higher wound closure, angiogenesis, re-epithelialization, and collagen deposition were observed for wounds treated with Heparin-aFGF hydrogel compared to control groups.	[150]
Gelatin	PRP	100 μL in 6 mm diameter hydrogel disc	+	More wound contraction, epithelialization, and capillary formation for PRP-Gelatin hydrogel in vivo when exposed to a wound model compared to the control group.	[156]
Poly (D, l-lactide)-poly (ethylene glycol)-poly (D, l-lactide) (PLEL)	PRP	10% v/v	+	PRP/PLEL induced EaHy926 proliferation and migration in vitro. & Improved wound closure, angiogenesis, and collagen deposition when applied to a rodent wound model compared to PLEL.	[151]
Gelatin	Interleukin 8 (IL-8) & macrophage inflammatory protein-3α (MIP-3α)	10 μg/mL	+	Stable release of chemokines from hydrogels within 7 days. Enhanced re-epithelialization, vascularization, and collagen deposition	[158]