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Prominent cerebral microvascular amyloid in rTg-DI rats but not in SHR-SP rat brain. Brain sections from 12-month WT (A, D, G), rTg-DI (B, E, H), and SHR-SP (C, F, I) rats were immunolabeled with rabbit polyclonal antibody to collagen IV to specifically detect cerebral microvessels (red) and stained with thioflavin S to identify fibrillar amyloid (green). Cerebral microvascular fibrillar amyloid deposits are only observed in rTg-DI rats. Scale bars = 50 µm.
