Fig. 9.

Application of EV-loaded hydrogels in heart

(A) (ⅰ) Schematic illustration of pericardial cavity injection and in situ formation of cardiac patch; (ⅱ) H&E staining showing the formation of a cardiac patch 7 days after pericardial cavity injection. Adapted reprinted with permission from Ref. [217], based on CC BY License. (B) (ⅰ) Schematic of injection-free delivery of EVs and (ⅱ) gelation mechanism of GelMA; (ⅲ) In situ crosslinking of EVs-loaded GelMA. (ⅳ) H&E staining. Adapted reprinted with permission from Ref. [27], Copyright @ 2021 Wiley-VCH GmbH (License number: 5,441,200,952,149).