Fig. 1.

Schematic illustration of the Pt(IV) prodrug initiated photo-polymerized microparticles (M_ICG-Pt) from microfluidic electrospray for synergistic tumor chemo-, photothermal and photodynamic therapy. (a) During the photo-activation of Pt(IV) to high cytotoxic Pt(II) species for chemotherapy, N₃^• and oxygen could also simultaneously generated. The N₃^• could induce the polymerization of GelMA matrix, ensuring the successful encapsulation of Pt(II) and ICG into the GelMA microparticles during microfluidic electrospray. Meanwhile, the oxygen could enhance the PDT efficacy of ICG. (b) After injection into the tumor site, the M_ICG-Pt could efficiently eradicate the cancer cells for inhibiting the tumor growth via synergistic chemotherapy, PTT and PDT.