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. 2022 Dec 22;24:185–196. doi: 10.1016/j.bioactmat.2022.12.020

Fig. 4.

Fig. 4

In vitro simultaneous PTT/PDT effects of MICG-Pt. (a) Photothermal heating curves of different microparticles under 808-nm laser irradiation (0.6 W cm−2). (b) Photothermal heating curves of MICG-Pt with different laser power densities. (c) Temperature variation of MICG-Pt and ICG over five NIR-On/Off cycles (808-nm, 0.6 W cm−2, On or Off for 3 min). (d) Time-dependent UV absorption spectra of DPBF incubated with Pt(IV)&ICG (++) under 808-nm irradiation from 0 to 30 min (++) indicated that the Pt(IV) was firstly irradiation by UV light before adding ICG and then irradiated by NIR laser. (e) Comparison of the decay rate of DPBF at 422 nm after incubation with Pt(IV)&ICG (+) or Pt(IV)&ICG (++) solution under the 808-nm irradiation. (+) indicated that the Pt(IV) was not irradiation by UV light before adding ICG. (f) Time-dependent UV absorption spectra of DPBF incubated with different microparticles with or without 808-nm laser irradiation for 30 min. (g) Intracellular ROS detection by incubating DCFH-DA with different microparticles under the 808-nm laser irradiation at 0.6 W cm−2 for 5 min.