FIGURE 1.

Metabolic changes of astrocytes in neurodegenerative diseases. In neurodegenerative diseases, the exchange of metabolites among astrocytes, neurons, and microglia has changed greatly, which aggravates the occurrence and development of neurodegenerative diseases. Astrocytes lose their homeostasis function. On the one hand, they are reactive to inflammatory factors of microglia. On the other hand, they fail to support the health of neurons. In addition, they also secrete many toxic factors that affect neurons.