TABLE 3.

Correlations between systemic inflammation and liver fibrogenesis/matrix turnover

	CRP (mg/dl)	p‐value	IL‐6 (pg/ml)	p‐value	PCT (ng/ml)	p‐value	LBP (μg/ml)	p‐value
ELF score	0.356 (0.23–0.47)	<.001	0.424 (0.30–0.53)	<.001	0.505 (0.39–0.60)	<.001	−0.148 (−0.28‐[−]0.01)	.030
PRO‐C3 (ng/ml)	0.342 (0.21–0.46)	<.001	0.322 (0.19–0.44)	<.001	0.445 (0.33–0.55)	<.001	0.000 (−0.13–0.13)	.999
PRO‐C6 (ng/ml)	0.289 (0.16–0.41)	<.001	0.420 (0.30–0.53)	<.001	0.412 (0.29–0.52)	<.001	0.096 (−0.04–0.23)	.161
TIMP1 (ng/ml)	0.446 (0.33–0.55)	<.001	0.554 (0.45–0.64)	<.001	0.500 (0.39–0.60)	<.001	0.265 (0.13–0.39)	<.001
C3M (ng/ml)	0.416 (0.29–0.52)	<.001	0.354 (0.23–0.47)	<.001	0.240 (0.11–0.37)	<.001	0.140 (0.00–0.27)	.041

Note: Statistical Analysis: Correlation analyses were performed by calculating Spearman's ρ with 95% confidence intervals (in brackets). p‐values <.05 are indicated in bold.

Abbreviations: C3M, neo‐epitope of MMP‐9 mediated degradation of type III collagen; CRP, C‐reactive protein; ELF, enhanced liver fibrosis; IL‐6, interleukin‐6; LBP, lipopolysaccharide binding protein; PCT, procalcitonin; PRO‐C3, released N‐terminal pro‐peptide of type III collagen; PRO‐C6, C‐terminal of released C5 domain of type VI collagen α3 chain; TIMP1, tissue inhibitor of metalloproteinases‐1.