Figure 7.

Proposed mechanism for regulation of osteoclast recruitment and differentiation by primary cilium and PTH1R in osteocytes. The presence of both functional primary cilium and PTH1R in osteocytes are necessary for correct communication with osteoclasts. Mechanical stimulation inhibits the recruitment and differentiation of osteoclasts through CXCL5, while PTH1R activation regulate osteoclasts through IL‐6. CXCL5, C‐X‐C Motif Chemokine Ligand 5; IL‐6, interleukin‐6; PTH1R, parathyroid hormone receptor type 1.