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. 2022 Aug 30;151(12):2161–2171. doi: 10.1002/ijc.34257

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© 2022 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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ROS1 immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) of a GOPC‐ROS1‐positive mCRC (index case). (A) Negative IHC with monoclonal anti‐rabbit antibody D4D6 (Cell Signaling Technology). (B) Positive IHC with monoclonal anti‐rabbit antibody SP384 (Ventana). (C) Negative FISH in GOPC‐ROS1 rearranged mCRC. Green dots: 6q22 ROS1 centromeric probe; orange dots: 6q22 ROS1 telomeric probe; overlapping or adjacent green and orange signals: negative result (no break‐apart). FFPE, formalin‐fixed paraffin embedded; FISH, fluorescence in situ hybridization; IHC, immunohistochemistry; mCRC, metastatic colorectal cancer