FIG 1.

Ratio of cerebrospinal fluid (CSF) to estimated unbound UCB0599 plasma concentration 2 hours after drug intake, by treatment group in UP0030 (phase 1 study in healthy participants [HPs]). Unbound plasma concentration is estimated by multiplying concentration by 0.011 (fraction unbound). Per protocol, plasma concentrations were measured at 2 hours post‐dose, shortly before CSF sampling. The symbol ◊ indicates the mean values of the calculated ratios in the boxplots. The concentrations of UCB0599 in the CSF increased linearly with increasing doses. BID, twice daily; CSF, cerebrospinal fluid; HPs, healthy participants; SD, single dose.