Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Aug 17;63(10):2684–2693. doi: 10.1111/epi.17385

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 The Authors. Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

PMC Copyright notice

Mean SEIzure interVALs (SEIVALs) for consistent cohort for Periods 1–4 (360 days; n = 76) with and without retreatments eliminated across time. To control for survival bias across time, consistent cohorts with one or more SEIVALs between seizure clusters in each period were examined. As Periods 1–4 included 360 days, this most closely matched the 12‐month treatment period of the phase 3 safety study of diazepam nasal spray. Here, second doses administered within 24 h of the first dose were eliminated from the analysis. This ensured that time between retreatments for the same seizure cluster (defined by 24 h) were not included. Mean SEIVALs for Periods 1–4 are shown for the subgroups of patients in consistent cohort with and without retreatments eliminated. **p < .01, ***p ≤ .001 compared with Period 1.