TABLE 1.
List of proteins included in this study, categorized based on their functions relevant to Endoplasmic reticulum (ER) structure and/or other functions, where relevant.
| Functions | Proteins | Origin | |
|---|---|---|---|
| ER structure | Tubules | Reticulons | Ancient |
| REEP5/Yop1p | Ancient | ||
| REEP1 | Unclear | ||
| Spastin | Ancient | ||
| Lunapark | Ancient | ||
| Protrudin | Holozoa | ||
| Arl6IP1 | Metazoa | ||
| ER junctions | Atlastin/Sey1p | Ancient | |
| Ufe1p‐Use1p‐Dsl1p | Ancient | ||
| Sheets | Reticulons | Ancient | |
| CLIMP‐63 | Metazoa | ||
| Kinectin | Metazoa | ||
| p180 | Metazoa | ||
| TMEM33 | Ancient | ||
| ER‐microtubules | STIM1 | Ancient | |
| Spastin | Ancient | ||
| CLIMP‐63 | Metazoa | ||
| REEP1 | Unclear | ||
| Endomembrane trafficking | Reticulons | Ancient | |
| Spastin | Ancient | ||
| Ufe1p‐Use1p‐Dsl1p | Ancient | ||
| TBC1D20 | Ancient | ||
| Yip3p | Ancient | ||
| VAPs | Ancient | ||
| Other functions | NogoR | Metazoa | |
| Caspr1 | Holozoa | ||
Note: Some proteins (e.g. reticulons) have multiple functions and are listed more than once. In the last column, the most probable point of origin of each is indicated, based on the results of the present study.