FIGURE 1.

Benefits of early treatment of diabetes to reduce latent cardiovascular disease (CVD) risk: The legacy effect. A, UK Prospective Diabetes Study (UKPDS): glycated haemoglobin (HbA1c) over time; B, UKPDS: cardiovascular (CV) outcomes; C, Diabetes Control and Complications Trial (DCCT)/ Epidemiology of Diabetes Interventions and Complications (EDIC): HbA1c over time; D, DCCT/EDIC: CV outcomes. MI, myocardial infarction. A, C and D Reprinted from Ramachandran et al. J Diabetes Metab. 2015;6:4 https://doi.org/10.4172/2155‐6156.1000520 under Creative Commons Attribution License. B From N Engl J Med., B Holman RR, et al. 10‐Year Follow‐up of Intensive Glucose Control in Type 2 Diabetes, 359, 1577‐89. Copyright © 2008. Massachusetts Medical Society. Reprinted with permission from Massachusetts Medical Society