TABLE 3.
Functional enrichment of the predicted genes targeted by the 12 differentially expressed microRNAs in patients with IRBD showing the 15 top enriched terms
| Enriched terms | P value | Adj. P value |
|---|---|---|
| Subcategory: Gene Ontology (GO) biological processes | ||
| Positive regulation of ubiquitin‐dependent protein catabolic process | 5.8 × 10−9 | 4.9 × 10−5 |
| Positive regulation of TRAIL‐activated apoptotic signaling pathway | 4.2 × 10−8 | 1.9 × 10−4 |
| Inositol‐1,3,4,5‐tetrakisphosphate 3‐phosphatase activity | 3.8 × 10−7 | 2.4 × 10−4 |
| Myelin sheath adaxonal region | 2.9 × 10−7 | 2.4 × 10−4 |
| Negative regulation of keratinocyte migration | 2.9 × 10−7 | 2.4 × 10−4 |
| Negative regulation of synaptic vesicle clustering | 2.9 × 10−7 | 2.4 × 10−4 |
| Neuron–neuron synaptic transmission | 2.0 × 10−7 | 2.4 × 10−4 |
| Phosphatidylinositol‐3,4,5‐trisphosphate 3‐phosphatase activity | 3.0 × 10−7 | 2.4 × 10−4 |
| Phosphatidylinositol‐3,4‐bisphosphate 3‐phosphatase activity | 2.9 × 10−7 | 2.4 × 10−4 |
| Postsynaptic density assembly | 9.9 × 10−8 | 2.4 × 10−4 |
| Prepulse inhibition | 4.0 × 10−7 | 2.4 × 10−4 |
| Regulation of cellular component size | 2.9 × 10−7 | 2.4 × 10−4 |
| Rhythmic synaptic transmission | 4.0 × 10−7 | 2.4 × 10−4 |
| Synapse maturation | 3.4 × 10−7 | 2.4 × 10−4 |
| Brain morphogenesis | 7.2 × 10−7 | 2.4 × 10−4 |
| Subcategory: KEGG pathways | ||
| Amyotrophic lateral sclerosis (ALS) | 1.3 × 10−4 | 0.0112 |
| Apoptosis—multiple species | 1.5 × 10−4 | 0.0112 |
| Carbohydrate digestion and absorption | 2.1 × 10−4 | 0.0112 |
| Epithelial cell signaling in Helicobacter pylori infection | 2.5 × 10−4 | 0.0112 |
| Fc epsilon RI signaling pathway | 2.1 × 10−4 | 0.0112 |
| GnRH secretion | 1.5 × 10−4 | 0.0112 |
| Toll‐like receptor signaling pathway | 1.0 × 10−4 | 0.0112 |
| PD‐L1 expression and PD‐1 checkpoint pathway in cancer | 3.6 × 10−4 | 0.0145 |
| Central carbon metabolism in cancer | 6.7 × 10−4 | 0.0238 |
| African trypanosomiasis | 0.0010 | 0.0247 |
| C‐type lectin receptor signaling pathway | 9.5 × 10−4 | 0.0247 |
| Proteasome | 0.0011 | 0.0247 |
| Pyrimidine metabolism | 0.0010 | 0.0247 |
| Salmonella infection | 8.3 × 10−4 | 0.0247 |
| TGF‐ß signaling pathway | 0.0012 | 0.0247 |
| TNF signaling pathway | 0.0012 | 0.0247 |
| Subcategory: localization (RNALocate) | ||
| Exosome | 2.0 × 10−8 | 2.0 × 10−7 |
| Cytoplasm | 1.3 × 10−7 | 6.5 × 10−7 |
| Microvesicle | 6.9 × 10−7 | 2.3 × 10−6 |
| Mitochondrion | 1.4 × 10−5 | 3.5 × 10−5 |
| Nucleus | 2.2 × 10−5 | 4.3 × 10−5 |
| Extracellular vesicle | 2.8 × 10−5 | 4.6 × 10−5 |
| Circulating | 4.8 × 10−5 | 6.9 × 10−5 |
| Nucleolus | 1.5 × 10−4 | 1.9 × 10−4 |
| Exosome | 0.0167 | 0.0185 |
| Microvesicle | 0.0194 | 0.0194 |
IRBD, isolated rapid eye movement sleep behavior disorder; KEGG, Kyoto Encyclopedia of Genes and Genomes; TGF‐ß, transforming growth factor ß; TNF, tumor necrosis factor; TRAIL, tumor necrosis factor‐related apoptosis‐inducing ligand; GnRH, Gonadotropin‐Releasing Hormone; PD‐L1, programmed cell death ligand 1; PD‐1, programmed cell death 1.