Mammalian	Farmed environment
Pathogen	Bacteria, viruses and so on	Aphids, beetles and so on
Treatment	Antibacterials, antivirals …	Pesticides
Administration	Daily dosing at fixed levels	Ad hoc application
Pharmacodynamic parameters	Potency	Potency
	Affinity	Affinity
	Selectivity	Selectivity
Pharmacokinetic parameters	Absorption	Application route
	Distribution	Translocation from soil
	Metabolism	Metabolism (species‐specific)
	Excretion	Run‐off into waterways
	Plasma steady state levels	Persistence (beyond need)
	Therapeutic window	EC50/DC50 or RC/DC50
	Safety margin	Safety margin
Toxicological impact	Microbiome	Microbiomes of species
	Organ damage (e.g.,liver and kidneys)	Bystander species (e.g. bees) and secondary exposure (e.g. aquatic taxa)
Co‐morbidities	Polypharmacy
	Drug:drug interactions	Pesticide:pesticide interactions
Chronic exposure	Tolerance	Unknown
	Dependence	Unknown
	Withdrawal	Unknown
	Resistance (pathogen evasion or host enzyme/transporter induction)	Resistance (pest evasion)