Table 3.
Odds Ratios (OR) and 95% Confidence Intervals (CI) for the Associations Between Serum Chemokines and the Risk of Developing Hip Fracture, the Singapore Chinese Health Study
| Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | p trend | Per 10% increment b | |
|---|---|---|---|---|---|---|
| Men | ||||||
| CXCL9 (pg/mL), median (IQR) | 1170.0 (851.3, 1404.7) | 1747.0 (1590.7, 1855.3) | 2378.7 (2226.7, 2592.7) | 3652.0 (3094.0, 4422.0) | 2385.0 (1656.0, 3415.3) | |
| Cases/controls | 5/14 | 8/14 | 13/14 | 29/13 | 55/55 | |
| Age‐adjusted OR (95% CI) | Ref. | 2.25 (0.31, 16.54) | 5.90 (1.00, 34.99) | 11.18 (2.03, 61.74) | 0.002 | 1.18 (1.07, 1.31) |
| Overall adjusted OR (95% CI) a | Ref. | 1.81 (0.21, 15.76) | 6.12 (0.98, 38.24) | 10.35 (1.90, 56.39) | 0.002 | 1.17 (1.06, 1.29) |
| CXCL10 (pg/mL), median (IQR) | 46.0 (42.2, 49.7) | 56.1 (54.2, 57.3) | 65.5 (61.2, 69.4) | 90.7 (80.7, 109.1) | 61.3 (53.7, 74.6) | |
| Cases/controls | 11/14 | 6/14 | 23/14 | 15/13 | 55/55 | |
| Age‐adjusted OR (95% CI) | Ref. | 0.52 (0.14, 1.97) | 3.28 (0.98, 10.99) | 2.40 (0.68, 8.42) | 0.15 | 1.08 (0.96, 1.22) |
| Overall adjusted OR (95% CI)a | Ref. | 0.43 (0.09, 2.11) | 3.59 (0.98, 13.14) | 2.71 (0.70, 10.55) | 0.18 | 1.10 (0.97, 1.26) |
| Women | ||||||
| CXCL9 (pg/mL), median (IQR) | 1101.3 (811.3, 1267.3) | 1688.7 (1559.3, 1890.0) | 2538.7 (2266.7, 2896.0) | 5329.7 (4052.3, 9008.0) | 2231.0 (1492.0, 3660.0) | |
| Cases/controls | 24/30 | 21/30 | 39/30 | 35/29 | 119/119 | |
| Age‐adjusted OR (95% CI) | Ref. | 0.92 (0.40, 2.14) | 1.66 (0.76, 3.61) | 1.67 (0.74, 3.75) | 0.15 | 1.02 (0.98, 1.05) |
| Overall adjusted OR (95% CI) a | Ref. | 0.83 (0.33, 2.10) | 1.79 (0.78, 4.14) | 1.46 (0.59, 3.60) | 0.32 | 1.02 (0.98, 1.06) |
| CXCL10 (pg/mL), median (IQR) | 48.1 (41.8, 54.7) | 65.5 (62.7, 70.7) | 83.6 (79.0, 89.3) | 119.2 (109.3, 174.6) | 71.7 (58.0, 97.8) | |
| Cases/controls | 37/30 | 35/30 | 16/30 | 31/29 | 119/119 | |
| Age‐adjusted OR (95% CI) | Ref. | 0.90 (0.44, 1.84) | 0.42 (0.19, 0.97) | 0.80 (0.39, 1.64) | 0.54 | 0.99 (0.94, 1.04) |
| Overall adjusted OR (95% CI) a | Ref. | 0.77 (0.35, 1.67) | 0.45 (0.18, 1.11) | 0.71 (0.32, 1.58) | 0.48 | 0.98 (0.93, 1.04) |
a
Adjusted for age at blood draw (years, continuous), body mass index (kg/m2, continuous), history of smoking (never, ever), and history of diabetes mellitus (yes, no).
b
For every 10% increment in serum chemokine levels (pg/mL, continuous).