Table 1.
Included studies and consortia*
| Data source/outcome | Outcome | Ancestry | No. of patients | No. of controls | Adjustments in the GWAS |
|---|---|---|---|---|---|
| CARDIoGRAMplusC4D and UKBB | |||||
| CAD | Mixed | 122,733 | 424,528 | Not reported | |
| MEGASTROKE consortium | |||||
| All stroke | European | 40,585 | 406,111 | Age and sex | |
| Any ischemic stroke | European | 34,217 | 406,111 | Age and sex | |
| Large artery stroke | European | 3,373 | 406,111 | Age and sex | |
| Small vessel stroke | European | 5,386 | 406,111 | Age and sex | |
| Cardioembolic stroke | European | 7,193 | 406,111 | Age and sex | |
| ISGC Intracerebral hemorrhage | European | 3,223 | 3,725 | Age, sex, and principal components | |
| GWAS by Bakker et al Subarachnoid hemorrhage | European | 5,140 | 71,952 | Not reported | |
| UKBB | |||||
| All stroke | European | 12,036 | 355,525 | Age, sex, and 10 genetic principal components | |
| Any ischemic stroke | European | 6,566 | 360,995 | Age, sex, and 10 genetic principal components | |
| Intracerebral hemorrhage | European | 1,504 | 366,057 | Age, sex, and 10 genetic principal components | |
| Subarachnoid hemorrhage | European | 1,292 | 366,269 | Age, sex, and 10 genetic principal components | |
| FinnGen consortium | |||||
| CAD | European | 30,952 | 187,840 | Age, sex, first 10 genetic principal components, and genotyping batch | |
| All stroke | European | 18,661 | 166,201 | Age, sex, first 10 genetic principal components, and genotyping batch | |
| Any ischemic stroke | European | 10,551 | 202,223 | Age, sex, first 10 genetic principal components, and genotyping batch | |
| Intracerebral hemorrhage | European | 1,687 | 201,146 | Age, sex, first 10 genetic principal components, and genotyping batch | |
| Subarachnoid hemorrhage | European | 1,338 | 201,230 | Age, sex, first 10 genetic principal components, and genotyping batch |
*
GWAS = genome‐wide association study; CARDIoGRAMplusC4D = Coronary Artery Disease Genome‐wide Replication and Meta‐analysis plus The Coronary Artery Disease Genetics consortium; UKBB = UK Biobank; CAD = coronary artery disease; ISGC = International Stroke Genetic Consortium.