TABLE 2.
Results at 6 months post ELVR
| EPF group N = 14. | Baseline | 6 months post ELVR | p value |
|---|---|---|---|
| Panel 1—EPF (CV positive group) | |||
| Post‐BD FEV1 (% predicted) | 28.2 (5.4) | 34.7 (7.9) | <0.01 |
| Post‐BD FEV1 (ml) | 0.75 (0.18) | 0.90 (0.28) | <0.01 |
| Post‐BD FVC (% predicted) | 73.5 (14.0) | 82.7 (14.7) | <0.01 |
| TLC (% predicted) | 129.1 (16.3) | 122.9 (16.4) | <0.01 |
| RV (% predicted) | 217.2 (39.0) | 190.62 (34.3) | <0.01 |
| RV (L) | 5.22 (0.91) | 4.53 (0.68) | <0.01 |
| DLCO (% predicted) | 41.2 (14.2) | 43.6 (13.6) | NS |
| DLCO (ml/min/mm Hg) | 9.94 (3.64) | 10.33 (3.62) | NS |
| KCO (% predicted) | 53.9 (17.2) | 61.0 (18.9) | <0.01 |
| KCO (ml/min/mm Hg/L) | 2.15 (0.74) | 2.38 (0.83) | <0.01 |
| 6MWD (m) a | 298.8 (97.3) | 376.0 (123) | <0.01 |
| SGRQ | 62.2 (12.8) | 47.1 (13.7) | <0.01 |
| Left upper lobe volume (ml) | 1957.5 (544.2) | 1062.9 (547.8) | <0.01 |
| EBV‐CTRL group N = 14 | Baseline | 6 months post ELVR | p value |
|---|---|---|---|
| Panel 2—EBV‐CTRL group (CV negative) | |||
| Post‐BD FEV1 (% predicted) | 31.2 (8.9) | 39.0 (7.5) | <0.01 |
| Post‐BD FEV1 (ml) | 0.76 (0.28) | 0.96 (0.30) | <0.01 |
| Post‐BD FVC (% predicted) | 76.2 (24.8) | 81.3 (11.9) | <0.01 |
| TLC (% predicted) | 127.1 (17.7) | 119.8 (19.9) | <0.01 |
| RV (% predicted) | 207.1 (32.8) | 172.9 (38.2) | <0.01 |
| RV (L) | 4.36 (0.96) | 3.68 (0.67) | <0.01 |
| DLCO (% predicted) | 34.8 (11.8) | 36.6 (8.7) | NS |
| DLCO (ml/min/mm Hg) | 7.97 (3.20) | 8.22 (2.41) | NS |
| KCO (% predicted) | 47.8 (13.9) | 52.2 (14.2) | <0.01 |
| KCO (ml/min/mm Hg/L) | 2.04 (0.58) | 2.21 (0.65) | <0.01 |
| 6MWD (m) | 289.7 (100.8) | 372.0 (67.6) | <0.01 |
| SGRQ | 57.3 (9.7) | 40.7 (10.6) | <0.01 |
| Left upper lobe volume (ml) | 1561.7 (429.5) | 862.3 (492.1) | <0.01 |
Note: Data are presented as n (%) or mean ± SD, unless otherwise stated.
Abbreviations: BD, bronchodilator; CV, collateral ventilation; DLCO, diffusing capacity for carbon monoxide; EBV‐CTRL, endobronchial valve control group; ELVR, endoscopic lung volume reduction; EPF, endobronchial polymer foam; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; RV, residual volume; TLC, total lung capacity.
a
n = 12 ‐ as 2 subjects from rural areas were unable to travel to have 6MWD performed in an appropriate timeframe.