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Schematic representation of relationships between type 2 diabetes and periodontitis. A combination of host genetic variants, microbiome, and lifestyle factors (some of them shared) seem to predispose to both conditions. Furthermore, a bidirectional association exists, with the presence of diabetes affecting periodontal disease and, in turn, periodontal disease affecting diabetes. AGE: advanced glycation end‐product; RAGE: receptor for advanced glycation end‐product
