FIGURE 2.

The predictive performance of computational methods on pharmacogenomic variants remains overall limited. (A) Predictive accuracy of commonly used functional prediction, conservation and ensemble methods when applied to pharmacogenomic variants with experimentally characterized functions. Dataset adapted from Zhou et al. ⁵¹ and Russell et al. ⁵² (B) Quantitative functional prediction of well‐characterized pharmacogenomic star alleles and their correlation (Pearson's r) to in vitro activity. Variants whose function could not be predicted with the algorithm in question are shown in grey. Figure modified with permission from Zhou and Lauschke ⁵³