Table 1.

Cohort summary statistics

Characteristics		Mild (n = 119)	Severe (n = 116)	All (n = 235)	Cohen’s d
Longitudinal ARMSS score	Median (IQR)	1.21 (0.72, 1.86)	8.63 (7.86, 9.20)	2.86 (1.20, 8.62)	8.87
	Range	0.17–3.01	6.52–9.92	0.17–9.92
Disease course at blood collection	RRMS	118 (99.2%)	46 (39.6%)	163 (69.4%)	–
	SPMS	0 (0.0%)	70 (60.4%)	71 (30.6%)
Disease course at most recent visit	RRMS	117 (98.3%)	39 (33.6%)	157 (66.8%)
	SPMS	1 (0.008%)	77 (66.4%)	78 (33.2%)
Sex	Female	119 (100.0%)	116 (100.0%)	235 (100.0%)	–
	Male	0 (0%)	0 (0%)	0 (0%)
Age at most recent visit	Median (IQR)	53.57 (45.92, 62.14)	53.47 (45.34, 61.33)	52.41 (43.81, 59.31)	0.15
	Range	29.00–76.35	28.80–76.35	28.80–76.21
Age at blood collection	Median (IQR)	49.10 (40.75, 57.62)	48.40 (40.10, 56.50)	47.80 (39.85, 55.35)	0.11
	Range	24.10–72.20	24.00–73.00	24.00–73.00
Symptom duration (years)	Median (IQR)	15.90 (11.45, 20.98)	24.18 (19.65, 31.70)	19.92 (13.79, 26.49)	0.95
	Range	5.85–38.11	11.91–47.13	5.85–47.13
ARR	Median (IQR)	0.10 (0.00, 0.20)	0.17 (0.00, 0.38)	0.11 (0.00, 0.26)	0.39
	Range	0.00–0.82	0.00–1.08	0.00–1.08
DMT at blood collection	Yes	84 (70.5%)	68 (58.6%)	152 (64.7%)	–
	No	35 (29.5%)	48 (41.4%)	83 (35.3%)
Follow-up in MSBase (years)	Median (IQR)	11.76 (10.24, 14.24)	11.27 (9.78, 13.29)	11.13 (9.49, 12.59)	0.25
	Range	5.15–21.96	5.15–32.16	5.26–32.16
Number of EDSS scores assessed	Median (IQR)	15.00 (11.00, 21.25)	15.00 (11.00, 19.00)	14.00 (10.00, 18.00)	0.29
	Range	3.00–47.00	3.00–47.00	3.00–34.00

ARMSS age-related multiple sclerosis severity score, IQR interquartile range, EDSS expanded disability status scale, ARR annualised relapse rate, DMT disease-modifying therapy

*MS course data missing for one patient