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. 2022 Aug 2;179(21):4958–4973. doi: 10.1111/bph.15921

FIGURE 4.

FIGURE 4

Simultaneous inhibition of SVEP1 and integrin α4 or α9 does not induce additional [Ca2+]i elevation in iVSMCs were treated with non‐targeting control (NTC), ITGA4, ITGA9 or SVEP1 siRNA for 48 h, or the dual integrin α4β1‐α9β1 inhibitor BOP for 2 h prior to Fluo3 loading and ET‐1 (50 nM) challenge for 45 s. Maximal fluorescence signal (F/F0) are shown (a) n = 8, (b) NTC, ITGA4, ITGA9 n = 5, SVEP1 n = 4, (c) NTC, BOP n = 9, SVEP1 n = 10, SVEP1 and BOP n = 11. Data presented are individual values with means ± SD. *P < 0.05, significantly different as indicated; one‐way ANOVA followed by Tukey's post hoc test.