TABLE 3.
Risk of bias in the included trials
| Risk of bias domain (assessment for the effect of assignment to intervention) | Overall risk of bias | |||||
|---|---|---|---|---|---|---|
| Outcome and study | 1. Randomization process | 2. Deviations from intended interventions | 3. Missing outcome data | 4. Measurement of the outcome | 5. Selection of the reported result | |
| All‐cause mortality | ||||||
| Lye et al., 2017 | Low | Low | Some concerns | Low | Low | Some concerns |
| Murphy et al., 1982 | Some concerns | Some concerns | Low | Low | Some concerns | Some concerns |
| Solomon et al., 1978 | Some concerns | Some concerns | Low | Low | Some concerns | Some concerns |
| Stanworth et al., 2013 | Low | Low | Low | Low | Low | Low |
| Wandt et al., 2013 | Low | Some concerns | Low | Low | Some concerns | Some concerns |
| Clinically important bleeding | ||||||
| Grossman et al., 1980 | High | Low | Low | High | Some concerns | High |
| Lye et al., 2017 | Low | Low | Some concerns | High | Low | High |
| Murphy et al., 1982 | Some concerns | Some concerns | Low | High | Some concerns | High |
| Stanworth et al., 2013 | Low | Low | Low | Some concerns | Low | Some concerns |
| Wandt et al., 2012 | Low | Some concerns | Low | Some concerns | Some concerns | Some concerns |
| Days with clinically important bleeding | ||||||
| Murphy et al., 1980 | Some concerns | Some concerns | Low | High | Some concerns | High |
| Stanworth et al., 2013 | Low | Low | Low | Some concerns | Low | Some concerns |
| Nosocomial infection | ||||||
| Stanworth et al., 2013 | Low | Low | Low | Some concerns | Low | Some concerns |
| Transfusion related adverse events | ||||||
| Lye et al., 2017 | Low | Some concerns | Some concerns | Some concerns | Low | Some concerns |
| Stanworth et al., 2013 | Low | Low | Low | Some concerns | Low | Some concerns |
| Wandt et al., 2012 | Low | Some concerns | Low | Some concerns | Some concerns | Some concerns |
| Length of hospital stay | ||||||
| Lye et al., 2017 | Low | Some concerns | Some concerns | Some concerns | Low | Some concerns |
| Stanworth et al., 2013 | Low | Low | Low | Some concerns | Low | Some concerns |
| Wandt et al., 2012 | Low | Some concerns | Low | Some concerns | Some concerns | Some concerns |
| Any bleeding (sensitivity analysis) | ||||||
| Assir et al. 2013 | Some concerns | Some concerns | Low | High | Some concerns | High |
| Grossman et al., 1980 | High | Low | Low | High | Some concerns | High |
| Lye et al., 2017 | Low | Low | Some concerns | High | Low | High |
| Murphy et al., 1982 | Some concerns | Some concerns | Low | High | Some concerns | High |
| Stanworth et al., 2013 | Low | Low | Low | Some concerns | Low | Some concerns |
| Wandt et al., 2012 | Low | Some concerns | Low | Some concerns | Some concerns | Some concerns |
| Days with any bleeding (sensitivity analysis) a | ||||||
| Murphy et al., 1980 | Some concerns | Some concerns | Low | High | Some concerns | High |
| Stanworth et al., 2013 | Low | Low | Low | Some concerns | Low | Some concerns |
| Long term all‐cause mortality (>90 days) (Sensitivity analysis) | ||||||
| Murphy et al., 1982 | Some concerns | Some concerns | Low | Low | Some concerns | Some concerns |
a
Wandt et al. (2012) did not report days with clinically important bleeding with individual patients as the unit of analysis and hence the study was not included in risk of bias assessment for that outcome.