TABLE 5.
Protection obtained with P30P2MSP119 in previous Aotus trials after challenge with P. falciparum FVO parasites
| Study | Species | No. of vaccinations | Dose (μg) | No. (%) of animals:
|
|||
|---|---|---|---|---|---|---|---|
| Total | Self-cured | Cured for anemia | With virulent parasitemia | ||||
| 23 | A. nancymai | 3 | 250d | 2a | 2 | 0 | 0 |
| A. vociferans | 2a | 0 | 0 | 2c | |||
| 11 | A. vociferans | 4 | 200e | 4a | 3 | 0 | 1 |
| 4b | 1 | 2 | 1 | ||||
| 22 | A. nancymai | 3 | 250d | 10a | 7 | 2 | 1c |
| A. vociferans | 2a | 0 | 1 | 1 | |||
| A. Egan et al., submitted for publication | A. nancymai | 4 | 200e | 3b | 1 | 1 | 1 |
| C. A. Long et al., unpublished data | A. vociferans | 4 | 200e | 7b | 2 | 0 | 5 |
| Total | A. nancymai | 15 | 10 (67) | 3 (20) | 2 (13) | ||
| A. vociferans | 19 | 6 (32) | 3 (4) | 10 (53) | |||
| This study | A. nancymai | 3 | 250d | 7a | 0 (0) | 3 (43) | 4 (57) |
a
Monkeys were challenged with 104 FVO P. falciparum parasites.
b
Monkeys were challenged with 105 FVO P. falciparum parasites.
c
Onset of parasitemia was delayed for one animal.
d
Vaccinations were given subcutaneously with CFA, followed by IFA, and followed by IFA.
e
The fourth vaccination was given intramuscularly without adjuvant.