Table 2.

Fifteen loci were found to be associated with delta age with at least suggestive significance ($p\le 1\times {10}^{-6}$).

Chr.	Gene	rsID	Pos.	Ref.	Alt.	AF	Effect size	$P$-value
14	SIPA1L1	rs35866366	71849185	A	G	0.25	0.52 (0.39, 0.64)	1.1e-15
6	VGLL2	rs6901720	117510203	G	T	0.47	0.43 (0.32, 0.54)	2.8e-14
4	CAMK2D	rs35430511	114387138	T	C	0.26	0.49 (0.36, 0.61)	3.1e-14
8	DEFB136	rs4240678	11802426	C	T	0.40	0.47 (0.32, 0.62)	4.9e-10
2	TTN	rs11902709	179608207	C	T	0.05	0.78 (0.52, 1.03)	3.0e-09
3	SCN5A	rs6773331	38684397	A	T	0.98	1.24 (0.82, 1.66)	9.1e-09
3	SCN10A	rs6801957	38767315	T	C	0.59	−0.32 (−0.43, −0.21)	2.1e-08
5	PKD2L2	rs10076361	137252940	G	A	0.18	0.41 (0.27, 0.55)	2.3e-08
8	EXT1	rs57237854	118860126	ATCTTG	A	0.18	0.40 (0.25, 0.54)	5.3e-08
10	AGAP5	rs147790633	75447582	T	C	0.14	−0.43 (−0.59, −0.27)	8.7e-08
10	CTNNA3	rs72799115	68008504	G	A	0.21	0.35 (0.22, 0.49)	2.0e-07
12	TBX3	rs1896329	115357432	C	T	0.69	−0.31 (−0.42, −0.19)	3.9e-07
2	SPTBN1	rs1802889	54756740	C	T	0.68	−0.30 (−0.42, −0.19)	4.4e-07
12	SOX5	rs12826024	24776799	G	A	0.15	−0.39 (−0.54, −0.24)	6.1e-07
16	CHD9	rs75778953	52906677	C	T	0.01	−1.25 (−1.74, −0.76)	6.2e-07

The second column lists the protein-coding gene closest to the respective lead variant. Positions correspond to the GRCh37 human genome assembly⁸¹. Values in parentheses denote the lower and upper bounds of the 95% confidence interval of the effect size estimate. $P$-values with genome-wide significance ($p\le 5\times {10}^{-8}$) are highlighted in bold. Chr., Chromosome; Pos., Position; Ref., Reference allele; Alt., Alternative allele; AF, frequency of the alternative allele.