Fig. 1.

Schematic showing targeted delivery of tissue- or cell line-derived mitochondria into injured spinal cords via Intraspinal (left) or Subdural (right) injection routes, both of which effectively transfer isolated mitochondria at and around the injury. Mitochondria genetically tagged with red fluorescent protein (RFP) and injected into the spinal cord accumulate as a bolus with tissue perturbation. Alternatively, subdural delivery of RFP⁺ mitochondria via erodible thermo hydrogels obviates parenchymal damage and allows their widespread distribution and graded uptake into host parenchymal cells. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)